The Loss of libido is an unfortunate condition that affects millions of women on a daily basis. Women from young to old can experience low sex drive at various stages of life: younger women may experience it after the birth of a child in their 20’s and 30’s; perimenopausal women usually during their late 30’s and 40’s; and both menopausal and postmenopausal women throughout the rest of their lives can all experience low libido. Many factors can play a role in a woman’s drop in sex drive and ability to enjoy sex. This decline can result from changes that are hormonal, physical, psychological, or relational. More specifically, some of the contributors to low female libido include: decreased testosterone and estrogen levels; vaginal dryness; medication side effects; chronic health conditions; loss of a spouse or partner; lack of emotional intimacy; conflict; stress; and mood concerns. A decrease in sex drive can also develop due to medical conditions or as the result of psychological or emotional issues.

Sex is not only an integral part of any relationship, but studies have proven it is beneficial to your health. A healthy sex life decreases stress and heart disease, while increasing happiness and sense of well-being.

Symptoms of sexual dysfunction in women

  • Low or absent sexual desire
  • Lack of arousal despite desire to have sex
  • Not able to maintain arousal during sex
  • Pain during sexual contact
  • Not able to experience an orgasm

Sexual dysfunction in women is quite often overlooked even though women suffer from sex issues just like men. While treatments for men experiencing erectile dysfunction are readily available many women are left wondering what options might be available to them. As a woman ages, there is a rapid decline in sex hormones such as estradiol and testosterone. Although women produce a much lower amount of testosterone than men, this decline is noticed throughout the whole body. Testosterone is responsible for a woman's sexual desire and responsiveness, mood, sense of well-being and mental acuity. As it does in men, Testosterone plays a role in maintaining a woman’s libido. Restoring optimal hormone balance can help improve your libido and reduce the symptoms of sexual dysfunction. When restoring hormones is not enough there are other treatment options available.

Treatment of Low Libido

A prescription topical all-in-one libido enhancement cream is available to treat the symptoms of sexual dysfunction in women.

libido enhancement cream for women

This proprietary formula has been developed by physicians who specialize in sexual health and hormone restoration. It contains a carefully measured combination of ingredients which work synergistically to increase direct blood flow, increase sensitivity, and improve desire. Testosterone can be added to the cream at a customized strength to address any hormone deficiency detected. Libido enhancement cream is compounded at a licensed pharmacy using a water based, hypoallergenic, transdermal vehicle and FDA approved medication.

The ingredients work to increase vaginal lubrication, relax vaginal muscles, increase sex drive, and improve sensation, lubrication, and sexual interest. Topical libido enhancers are an appealing alternative to oral medications. Inconsistent dosing and possible side effects can be eliminated with topical creams that are applied locally to increase sensitivity and blood flow.

Use: Apply directly to the clitoral area at least 30 minutes prior to anticipated sexual activity and gently massaged in. Duration of effect ranges from 30 minutes to 2 hours and heightens both ease of stimulation and intensity of orgasm.

Contraindications: Patients with a history of sensitivity to any of the listed ingredients should not use this product. Patients with a history of genital herpes should use this product with caution as L-Arginine may facilitate reproduction of the herpes virus. Libido enhancing cream is available without L-Arginine upon request. Onset is identical to the complete product but duration may be reduced. Libido enhancement cream can cause irritation in women who currently have a yeast infection. Do not apply cream until the infection is resolved.


The formulation below can be custom tailored to each individual’s needs upon request, 1mL dose generally contains the following ingredients. The amount applied is typically between 0.25ml-0.5ml.

  • Sildenafil Citrate 10mg - relaxes muscles and increases blood flow to particular areas of the body by increasing nitric oxide. Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men, and is purported to have similar libido enhancing effects on women. It works by inhibiting the enzyme (PDE-5) that prevents nitric oxide from relaxing specific tissues. Nitric Oxide is believed to have a primary role in the regulation of clitoral and vaginal blood flow.
  • L-Arginine 60mg - Research over the last three decades has shown that arginine’s main influence on metabolism and health is via Nitric Oxide production. L-Arginine remains the largest source of nitrogen in the body for NO production, its relevance and metabolism of NO has received much attention over the last decade. Nitric Oxide functions as: a Regulator of healthy blood pressure; a killer of bacteria and tumor cells; a messenger molecule to the brain involved in memory and thought process; a regulator of inflammation and the immune system; and many other important processes in the body. Increasing systemic levels of L-arginine has been demonstrated to significantly improve endothelial function in individuals with essential hypertension, compromised flow-mediated dilation, arterial stiffness, chronic heart failure, impaired glucose tolerance (MetS) and type 2 diabetes – all of which are common concomitant medical conditions associated with sexual dysfunction. L-Arginine is commonly sold as a health supplement claiming to improve vascular health and treat erectile dysfunction in men; and is purported to have similar libido enhancing effects on women.
  • Aminophylline 30mg - a bronchodilator that works in several ways: relaxes the muscles in your lungs and chest to allow greater airflow; decreases the sensitivity of your lungs to allergens and other substances that cause inflammation; and increases the contractions of your diaphragm to draw more air into the lungs for intense breathing. It is primarily used to treat the symptoms of asthma, bronchitis, and emphysema.
  • Papaverine 20mg - Increases blood flow by relaxing the blood vessels directly where applied. Papaverine is used to treat erectile dysfunction in men and also has other uses in medicine where relaxation of the blood vessels are required.
  • Isosorbide 2.5mg – Isosorbide is a vasodilator which means it dilates blood vessels to allow more blood flow to the area applied.
  • Testosterone 2.5mg – The Women's Health Institute at the University of New Jersey suggests that androgens (testosterone) play a significant role in affecting pre-menopausal and post-menopausal symptoms and quality of life. As it does in men, Testosterone also plays a role in maintaining a women’s libido. Testosterone supports bone density and muscle tissue. Increased bone density is critical because of the increased risk of osteoporosis women face as they age. Women produce their testosterone in the ovaries and adrenal glands and typically lose 70 percent of the hormone by the age of 40. This decrease can cause most, if not all the effects listed above. Some other effects of low testosterone in women include increased risk of cardiovascular disease (Med. Suisse Romande 2003 Mar) and increased risk of Alzheimer's (Cell mol Life Sci. 2005 Feb). A simple blood test can determine the level of testosterone in the body and therefore can detect a deficiency.

Libido enhancement cream can only be obtained with a prescription from a licensed physician. Take the first step by contacting Defy Medical to learn how you can receive your libido enhancement cream.


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  • 6. Urol Int . 1999;63(4):220-223. Effectiveness of oral L-arginine in first-line treatment of erectile dysfunction in a controlled crossover study. Klotz T, Mathers MJ, Braun M, Bloch W, Engelmann U.
  • 7. J Sex Marital Ther . 2003;29(3):207-213. Treatment of erectile dysfunction with pycnogenol and L-arginine. Stanislavov R, Nikolova V.
  • 8. Urology . 2009;74(4)(suppl):S330. Can L-arginine added to tadalafil improve the results on patients with erectile dysfunction non-responsive to tadalafil as monotherapy? Cumpanas A, Botoca M, Minciu R, Fahes M, Bucuras V, Miclea F.
  • 9. Eur J Endocrinol. 2006 Jun;154(6):899-906. Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women. Goldstat R, Briganti E, Tran J, Wolfe R, Davis SR.



Defy Medical strives to provide both quality medical care along with affordable access to compounded medications, blood tests, and nutritional supplements. In order to accomplish this, Defy Medical does not accept any form of insurance. Many of the formulations we use in our therapies are not covered by insurance, and the cost of overall treatment is often less than when using insurance. On case by case basis, some insurance companies do reimburse for Hormone Replacement Therapy and Testosterone Replacement Therapy. It is each patient's responsibility to contact their own insurance company to confirm reimbursement. Defy Medical will not contact your insurance company nor will take any responsibility for any additional forms your insurance requires. Defy Medical provides claim assistance by completing the standard claim form (CMS-1500) for the patient to submit to their insurance company. If you would like to receive Claim Assistance, please contact patient services at [email protected]