TriMix is commonly prescribed for:
  • Treatment of erectile dysfunction in males
Multiple strength combinations of TriMix are available:
  • Papaverine from 7.5mg/mL - 30mg/mL
  • Phentolamine Mesylate 0.25mg/mL - 2mg/mL
  • Prostoglandin E1 2.5mcg/mL - 20mcg/mL
The dosage form available for TriMix is Injection Solution. Empower Pharmacy’s injection solutions are compounded under the stringent USP 797 guidelines for sterile compounding, and sterility, endotoxin, potency and pH testing is performed on every batch. Our quality-assurance process ensures the consistency and uniformity of every solution for injection we dispense.

Pharmacologic Category:Anti-erectile dysfunction agent

What is this medicine used for?Treatment of erectile dysfunction in males. Tri-Mix contains three drugs mixed in a sterile injection. They are:
1.) Papaverine:A drug that causes blood vessels to expand (vasodilator): it produces an erection by increasing blood flow to the penis.
2.) Phentolamine:When injected into the penis, it produces an erection by increasing blood flow to the penis.
3.) Prostaglandin E-1:A potent hormone-like substance that can control blood pressure, helping produce erections.

Reasons not to take this medicine:Do not take this medicine with any of the following medications: hypersensitivity or allergy to any component of this formulation; conditions predisposing you to priapism (painful erection lasting 4 hours or more): sickle cell anemia, multiple myeloma or leukemia; anatomical deformation of the penis or with penile implants; direction by your physician that sexual activity is inadvisable or contraindicated.

Key warnings before taking this medicine?Tell your doctor if you have a condition or are taking a medicine that interferes with blood clotting.

What are the precautions when taking this medicine?Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Some items may interact with your medicine.

How is it best taken?Ideally, the injection should be administered just prior to foreplay. To prevent bruising, apply firm pressure to the injection site for 5 minutes after injection. It is administered via intra-cavernosal injections and should produce an erection in 5 to 20 minutes and can be expected to last up to one hour. Do not use Tri-Mix Injection more than 2 times a week; use at least 24 hours apart. There is a possibility of needle breakage with use of Tri-Mix Injection: you should pay careful attention to your doctor's instructions and handle syringe and needle properly. If the needle breaks during injection, you should promptly contact your doctor.

What do I do if I miss a dose?Do not take double or extra doses. This medicine should only be taken 5 to 20 minutes before intercourse.

What are some possible side effects of this medicine?Mild to moderate pain during injection; painful sensation with erection; small amount of bleeding at the injection site. Call your healthcare provider if you notice any redness, lumps, swelling, tenderness or curvature of the erect penis. If you experience an erection lasting more than 2 hours, you may take 2 - 4 pseudoephedrine 30 mg by mouth once and apply an ice pack. If your erection does not go away within the next hour, seek professional help immediately. Erections that last more than 6 hours can cause serious damage to penile tissue.

How should I store this medicine?The mixture is not stable for long periods. Our studies indicate that frozen preparations are stable for a year. Otherwise keep this medicine in a refrigerator below 41°F (5°C). It is important to note that improper storage does not result in harmful chemicals: the only thing to suffer is the potency - the preparation may not be as strong as when fresh. Keep all medicine out of the reach of children. Throw away any unused medicine after the expiration date. Do not flush unused medications or pour down a sink or drain.

General statements:Do not share or take any one else's medicine. Talk with your healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins. This medication was compounded specifically for you. This patient information summarizes the most important information about your medication; if you would like more information, talk with your doctor.

Tri-Mix is compounded under strict USP797 sterile guidelines at our compounding pharmacy




Defy Medical strives to provide both quality medical care along with affordable access to compounded medications, blood tests, and nutritional supplements. In order to accomplish this, Defy Medical does not accept any form of insurance. Many of the formulations we use in our therapies are not covered by insurance, and the cost of overall treatment is often less than when using insurance. On case by case basis, some insurance companies do reimburse for Hormone Replacement Therapy and Testosterone Replacement Therapy. It is each patient's responsibility to contact their own insurance company to confirm reimbursement. Defy Medical will not contact your insurance company nor will take any responsibility for any additional forms your insurance requires. Defy Medical provides claim assistance by completing the standard claim form (CMS-1500) for the patient to submit to their insurance company. If you would like to receive Claim Assistance, please contact patient services at [email protected]