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Defy Medical
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     October 2015

Announcement: Sermorelin Acetate 15mg now available for $165 ! (Normally $225)

Defy Medical is pleased to announce that our compounding pharmacy is now offering Defy Medical patients a discounted price for Sermorelin Acetate 15mg (15,000mcg) vials. The new price is $165 (normally $225). We are hoping the new price makes this medication more accessible to our patients who are interested in restoring Growth Hormone levels.

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All Sermorelin prescribed by Defy Medical is compounded by a licensed US Pharmacy. All Sermorelin is independently tested by a lab for purity, potency, and endotoxins. Contact us today if you would like to see a copy of the independent lab results from the pharmacy.

Sermorelin Quick Facts ?

What is Sermorelin Acetate?

Sermorelin(GHRH) is a bio-identical hormone that has recently been genetically engineered to stimulate the secretion of Growth Hormone Releasing Hormone (GHRH) from the hypothalamus, a gland adjacent to the pituitary gland. GHRH is a peptide that contains the first 29 amino acids of our own GH. These 29 amino acids are the active amino acids of GHRH. It is GHRH that stimulates the pituitary glands to release GH. As we get older, the hormones produced by the anterior pituitary are depleted. It has now been shown that GHRH can restore the Growth Hormone-RNA to a youthful level causing elevation of levels of IGF-1. Sermorelin acetate used to be sold by Serono as the brand name GEREF used for diagnosis or treatment of growth hormone deficiency. It was discontinued by the company of July 2008 as they picked up the rights of a more expensive growth hormone releasing hormone called tesamorelin. Sermorelin Acetate is now available at some US compounding pharmacies who specialize in making injectable peptides.

Click here to read "Introduction to Sermorelin Acetate" for more information.

How does Sermorelin come?

Sermorelin is presented in a multi-dosed, injectable vial. Each vial contains a powder disc which contains 15mg (15,000 micrograms) of lyophilized Sermorelin Acetate. The vial is vacuum sealed by the pharmacy for your protection and for the preservation of the hormone peptide. Each Sermorelin vial also comes with a bottle of Bacteriostatic Water as a diluent. The Bacteriostatic Water is mixed with the Sermorelin to provide solution for injection .

How do I take Sermorelin?

Sermorelin is injected into the body fat, subcutaneously, using a very small needle similar to what a diabetic uses to inject insulin. Injections are initially prescribed for every day and are decreased in frequency over time.

Click here to learn how to mix and inject Sermorelin

How do you measure the effectiveness of Sermorelin?

Due to the pulsatile nature of both endogenous HGH and IGF-1, a single blood draw is not sufficient for accurate measurement. Most physicians who prescribe Sermorelin and similar peptides measure effectiveness in patients through symptomology (the study of your symptoms-see benefits); physical appearance and measurements; and a Triple Specimen Growth Hormone blood test. This blood test can most accurately assess your response to growth hormones and gh stimulating peptides.

How will I know its working?

After 4 years of observing patients taking Sermorelin, I have noticed that patients usually report improved sleep within the first few weeks of therapy. Of course, this is only noticed in patients who have trouble sleeping in the first place, however most patients at least notice an increase in sleep quality. This is usually concurrent with increased energy levels and improved mood.

After 3-6 months of therapy patients start reporting noticeable or significant body changes, such as increase in muscle tone and a leaner physique.

Over time patients will also notice a significant improvement in skin tone and health.

How long does it take to work?

Just like most HGH medications, Sermorelin usually has a “loading” period of 3-6 months before full effects are noticed. Once injected, both Sermorelin and rHGH are eliminated from then body very quickly and therefore need to be injected frequently. Its actions are dependent on a chain reaction of biological processes which result in elevated and sustained HGH and growth factors. It takes some time for levels to become optimal and initiate the benefits we are seeking to achieve.

Do I need to take Sermorelin forever to keep seeing results?

Actually, no. Sermorelin has an ongoing effect in which optimal HGH levels can be sustained long after the last injection. Just like synthetic HGH, Sermorelin initially must be injected every day. Unlike synthetic HGH, once optimal levels are sustained with Sermorelin injection frequencies can be decreased or stopped altogether. Once results are achieved, patients are then switched to a maintenance protocol eliminating the need for ongoing daily injections and reducing the total cost of therapy!

Sermorelin Dosing protocol for optimizing Growth Hormone (GH)

Studies have shown that 1mg of Sermorelin will create maximum stimulation to the pituitary to create a good level of growth hormone within the pituitary. This dose should be used for approx. 6 months as the anterior pituitary is recrudesced. Therefore, a dose of aprox. 500mcg (1/2mg) delivered subcutaneously each evening has been shown to provide maximum stimulation to the pituitary releasing optimum endogenous growth hormone. After aproximatly 12 months of sermorelin injections, the patient can try reducing injection frequency to 1mg 2-3 times per week to maintain levels.

Again, because the manufacture of endogenous growth hormone by the pituitary is governed by a negative feedback loop, meaning that if the body recognizes that there is an optimum level of endogenous growth hormone being already being produced, then no matter how strongly stimulated by sermorelin, no more endogenous gh will be produced. Note that in truth, the relationship between sermorelin dosing and endogenous growth hormone production is not exactly linear. However, for purposes of discussion and materiality, the aforementioned relationships and limits between sermorelin and endogenous growth hormone are true. So it makes sense to utilize sermorelin to optimize growth hormone levels as determined by the patient’s response itself rather than use exogenous growth hormone through either guesswork or extensive repeated testing.

Using Sermorelin Acetate improve quality of life by increasing both production of Human Growth Hormone and increasing pituitary reserves of HGH. Sermorelin does not bypass the pituitary-GH axis therefore allowing control of GH release and subsequent growth factor production.

Measuring IGF-1 blood levels while using Sermorelin

Using Sermorelin Acetate works by increasing both production of Human Growth Hormone and by increasing pituitary reserves of HGH. Many patients mistakenly rely on IGF-1 testing as the sole measurement of how they are responding to Sermorelin. The best way to measure a patient’s response to Sermorelin is by administering a Triple Specimen Growth Hormone blood test. This blood test can most accurately assess your response to growth hormones and growth hormone stimulating peptides by measuring growth hormone levels before and immediately following a Sermorelin injection. IGF-1 can be tested along with the triple specimen GH to provide a more complete analysis.

Testing IGF-1 by itself is a double edged sword. When low doses of sermorelin are used, sometimes there is no increase in IGF-1

If you measure IGF-1 before Testosterone Replacement Therapy (TRT), it will likely increase after TRT and more so on HCG. Adding Sermorelin at low doses (under 500mcg) to the combo may not show a significant increase in IGF-1 and may discourage the patient to stay on the medication.

A study using sermorelin in adults used a dose of 1 to 2 mg per day to see if it had an effect on cognitive function. The product worked in achieving that goal. That dose increase GH levels by 100 percent and IGF-1 levels by 34 percent.

Using smaller doses like 0.1 to o.3 mg per day may result in IGF-1 level increases of less than 10-20 percent which may not be enough to be picked up by IGF-1 testing (due to error and variability). So, this needs to be taken into consideration if sermorelin is prescribed and IGF-1 levels at baseline and at 90 days.

Sermorelin: The better approach to management of adult-onset growth hormone insufficiency

Growth hormone replacement therapy (GHRT) using recombinant human growth hormone (rhGH) has been embraced by many age management practitioners as one of the most effective methods for opposing somatic senescence currently available. However, its routine use has been controversial because few clinical studies have been performed to determine the potential risks of long-term therapy.

Read Article

Growth Hormone (GH) Axis.
Diagram of the Growth Hormone (GH) Axis.
  • Growth Hormone Releasing Hormone (GHRH) is released by the hypothalamus gland.
  • GHRH then travels quickly to the pituitary where it stimulates the creation of Growth Hormone.
  • Growth Hormone is stored in the pituitary gland where it is released at certain times such as during sleep and intense exercise.
  • After being released, Growth Hormone then travels to target areas including the liver, bone, muscle, and fat.
  • Once GH is received by the liver, bone, and muscle tissue there is a release of Growth factors like Insulin-like-growth factor (IGF-1) which each have specific functions.
  • Sermorelin Acetate is a genetically engineered Growth Hormone Releasing Hormone

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Defy Medical is located in Tampa at:
4809 N. Armenia Ave.
Suite # 220
Tampa, FL 33603
Phone #:(813) 445-7342
Monday - Friday | 9:00 AM - 5:30 PM Eastern Standard Time
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