Diindolylmethane (DIM) is a stable indole found in cruciferous vegetables which promotes a beneficial estrogen metabolism in both women and men.  Post-menopausal women that take hormone replacement therapy can improve their estrogen metabolism with DIM. Among the other benefits DIM gives women is a lower chance of weight gain and maintain uterine, cervical breast health while decre asing the chances of cancer.

Supplementing your diet with DIM specifically promotes beneficial estrogen metabolism and helps restore a healthy hormonal balance.

An open label study of DIM in overweight men and women showed it promoted more efficient weight loss and more active fat metabolism.

Can Men Benefit from DIM?

Everyone knows estrogen is an important hormone for reproduction in women.  What is not often appreciated is that estrogen levels, though lower than those in women, are also essential in men.  However, midlife changes in men result in excess estrogen production beyond its minimal essential level. Like perimenopausal women, men experience a tendency to gain weight in midlife.  Fat cells contain the enzyme known as Aromatase, which converts Testosterone into Estrogen. This process is the primary source for estrogen in men.  Testosterone converts to estrogen naturally then breaks down into "bad" and "good" estrogen metabolites. DIM will improve this ratio by helping the body elimimate the bad estrogens. 

Supplemental Diindolylmethane DIM reduces the effects of un-metabolized estrogen and promotes the action of testosterone. It does this by maximizing the testosterone-to-estrogen ratio in the body, thus increasing the activity of testosterone. . . . Diindolylmethane DIM can improve mood, fight depression, and support memory. . . . Diindolylmethane DIM also can be used to help address many of the unwanted side effects of estrogen in men—particularly those that occur with the age-related accumulation of estrogen. . . . Diindolylmethane DIM can now be used to reduce the risk of prostate enlargement and promote a healthy prostate. Optimum testosterone-to-estrogen hormone balance achieved with the use of Diindolylmethane DIM can help to preserve a youthful urinary tract and prevent age-related prostate growth.  DIM blocks the estrogen receptors, interfering with their activity. This raises the ratio of testosterone to estrogen. With DIM causing an increase in free testosterone, this means a higher sex drive, better moods, muscle building and bone-strengthening from workouts. DIM may reduce the chance of an enlarged prostate because of estrogen presence. 

Diindolylmethane is a molecule that increases the breakdown of estrogens. Two indole-3-carbinol (I3C) molecules work together to support healthy estrogen balance. Increasing the ratio of 2-OHE1/16a-OHE1 may help improve health issues which are negatively affected by estrogens.

Defy Medical Offers High Quality DIM

Available by Metabolic Maintenance- 100mg capsules.  $34.00 for 60 capsules.

Available by Ortho Molecular -CDG EstroDIM -$69.90 for 60 capsules


Custom strengths and combinations are also available with the pharmacists approval.  Contact Defy patient services for more information.  A free consultation with an experienced medical assistant is available to discuss available options. 


  • Purohit A, Singh A, Ghi1chik MW, Reed MJ.  Inhibition of tumor necrosis factor alpha-stimulated aromatase activity by microtubule-stabilizing agents, pac1itaxel and 2-methoxyestradiol.  Biochem Biophys Res Commun. 1999; 261: 214-217.
  • Dulloo AG, Duret C, Rohrer D, et a1.  Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans.  Am J Clin Nutl: 1999; 70:1040-1045.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.