Diindolylmethane (DIM) is a stable indole found in cruciferous vegetables which promotes a beneficial estrogen metabolism in both women and men. Post-menopausal women that take hormone replacement therapy can improve their estrogen metabolism with DIM. Among the other benefits DIM gives women is a lower chance of weight gain and maintain uterine, cervical breast health while decre asing the chances of cancer.
Supplementing your diet with DIM specifically promotes beneficial estrogen metabolism and helps restore a healthy hormonal balance.
An open label study of DIM in overweight men and women showed it promoted more efficient weight loss and more active fat metabolism.
Metabolic Detox is a product designed to support the liver in detoxification processes. We combine the classic liver botanical Silymarin with antioxidants N-Acetyl Cysteine (NAC), Alpha Lipoic Acid and Selenium.
Medical providers at Defy Medical suggest Metabolic Detox when liver enzymes are elevated. Elevated liver enzymes may be a sign of a more serious medical problem and can lead to liver damage. As our medical team continues to monitor each patient’s blood work we have found that Metabolic Detox plays an important role in restoring liver health. Of course, in addition to the detoxification provided by Metabolic Detox, we must identify and treat the cause.
Defy Medical offers Adrenal Tea Capsules which are formulated at a specialty pharmacy which focuses on natural compounds, herbs, and nutritional formulas. Each batch is tested for quality and potency under the same standards as pharmaceutical medications. This formula is made by a pharmacy exclusively for medical doctors who focus on fatigue, stress, and adrenal function.
Adrenal Tea capsules costs $40 for 120 capsules. Each capsule is made per order at a specialty pharmacy and will ship directly to you. Adrenal Tea is only available at our pharmacy.
Take 2 capsules twice per day. Preferably upon waking up and again after lunch.
Improve energy, assist adrenal function, Reduce stress hormones, Treat Insomnia
Siberian Ginseng- adaptogen used to increase resistance to the stress reaction that occurs by improving the sensitivity of the HPA axis to cortisol. It is reported to have the ability to stimulate the immune and circulatory systems, regulate blood pressure, reduce inflammation, treat insomnia, and increase stamina.
Vitamin D is the name given to a vitally important group of micro-nutrients. When activated, vitamin D becomes a potent steroid hormone, switching our genes on or off, and instructing our cells what work to do. Vitamin D's effects are varied and profound. It is structurally similar to steroids such as testosterone, cholesterol, and cortisol (though vitamin D3 itself is a secosteroid). The term "vitamin D" refers to several different forms of this vitamin. Two forms are important in humans: ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3). Vitamin D2 is synthesized by plants. Vitamin D3 is synthesized by humans in the skin when it is exposed to ultraviolet-B (UVB) rays from sunlight. Foods may be fortified with vitamin D2 or D3, although human’s should not rely on synthetic food fortification as a good source of Vitamin D3.
Glycine is one of the non-essential amino acids and is used to help create muscle tissue and convert glucose into energy. It is also essential to maintaining healthy central nervous and digestive systems, and has recently been shown to provide protection via antioxidants from some types of cancer.
Glycine is used in the body to help construct normal DNA and RNA strands—the genetic material needed for proper cellular function and formation. It helps prevent the breakdown of muscle by boosting the body’s levels of creatine, a compound that helps build muscle mass. High concentrations of glycine are found not only in the muscles, but in the skin and other connective tissues as well. Almost 1/3 of collagen, which keeps the skin and connective tissue firm and flexible, is composed of glycine. (High amounts of Glycine are also found in gelatin, which is a form of denatured collagen). Without glycine the body would not be able to repair damaged tissues; the skin would become slack as it succumbed to UV rays, oxidation, and free radical damage, and wounds would never heal.
L-Glutamine- Glutamine is the most abundant amino acid in the bloodstream. It is most notable for its healing properties to the gastrointestinal tract and is helpful with ulcers, IBS, and gluten sensitivities.* Elevated cortisol levels from trauma (wounds, burns, surgeries) can deplete glutamine levels. In solution L-Glutamine is virtually tasteless. Glutamine is considered “anti-catabolic “which means it can help your body maintain muscle under stress or disease. Athletes use Glutamine for this purpose, to help muscles recover from exercise and to prevent the loss of muscle while dieting. Some people use glutamine for digestive system conditions such as stomach ulcers, ulcerative colitis, and Cohn’s disease.
Ever since human growth hormone (HGH) was first titled The Fountain of Youth, researchers have
studied the phenomenon that occurs when a hormonally deficient person is given physiological doses,
and seems to rapidly decrease in biological age.
It wasn't until 1997 that growth hormone deficiency was recognized as a clinical syndrome.
"Growth hormone deficiency is now formally recognized as a specific clinical syndrome, typified by
decreased muscle mass, increased body fat, decreased exercise capacity, osteopenia, abnormal lipid
profiles and diminished feeling of well being…"
(Inzucchi, Silvo; Hospital Practice, Jan. 15,1997).
We are all aware of the popularity Human Growth hormone has gained over the last few years. Everyone from athletes to celebrities and now some of us ‘regular folk’ have enjoyed the tremendous benefits of this powerful hormone. Human Growth Hormone is produced by the Pituitary Gland and is a very complex molecule. It promotes growth in children and plays an important role in adult metabolism. The body secretes the hormone, in decreasing amounts, throughout our lifetimes. The amount of HGH hormone in the body can be measured by levels of IGF-1 (Insulin Growth Factor). Growth hormone has a profound effect on all the cells of the body, more than any other hormone because it is THE cell generator. It is the "master hormone" controlling many organs and body functions and is directly responsible for stimulating tissue repair, cell replacement, brain functions, and enzyme function.
The most common forms of injectable testosterone include Testosterone Cypionate, Testosterone Propionate, and Testosterone Enanthate…or a 'blend' of some sort. I do not like testosterone "blends" do to irregular release patterns. Always remember that each of these forms is simply testosterone, the molecule remains unchanged, and the only difference is the "ester" which determines the half-life within the body. An 'ester' is basically a chain composed of Hydrogen, Carbon, and Oxygen atoms which are attached to the testosterone molecule which must be broken down creating a 'timed release" in the body once injected. Even though the testosterone molecule remains the same no matter the ester, each one can yield different results in patients.
Preparation: Nasal-Spray 50 units/ML; 5ML Vial
A restrospective study published this week on the Journal of American Medical Association concluded that testosterone may increase the risk of cardiovascular problems in men with a history of heart disease. This study performed at the Venteran’s Administration hospital sysmtem cautioned that men with pre-existing cardiovascular ailments who have low blood levels of testosterone (hypogonadism) might need to avoid testosterone replacement therapy (TRT) even if they need it to improve their lives.
Intravenous vitamin C – combined with conventional chemotherapy – can kill cancer cells, the University of Kansas Medical Center reported.
In a study of 27 patients newly diagnosed with stage 3 or stage 4 ovarian cancer, researchers found that patients who received a high-dose of intravenous vitamin C, along with conventional cancer therapy of paclitaxel or carboplatin, experienced fewer toxic effects from the chemotherapy drugs.
The media was again splattered with bad news about testosterone therapy this week. On Wednesday, Jan. 29, 2014, Finkle and colleagues published a study in the journalPlos One that exhibited an increased risk of heart attacks in testosterone users in the first 90 days of therapy, and the risk was higher in men who had had a history of cardiovascular disease. There are many problems with the data in this study and others like it that have lead to attention-grabbing headlines about how treatment of low testosterone levels may put men at undue risk. Similar to a November 2013JAMA study of testosterone risks that I reviewed in a prior post, this current study has multiple flaws that make its conclusions essentially meaningless. Neither study assessed testosterone levels of patients before and during therapy. There are other critical blood tests that should be done that were not being done during the treatment of the VA men or in the current study, including blood counts and estrogen levels. Higher red blood cell counts and higher estrogen levels are known issues that may occur in men given testosterone therapy. Without assessment of testosterone levels, red blood cell counts and estrogen levels prior to and during therapy, it is impossible to tell if a patient is a proper candidate for therapy and if they are tolerating the therapy well.
A published review of studies attempted to determine, from published studies, the time-course of the effects induced by testosterone replacement therapy from their first manifestation until maximum effects are attained.
This review found that:
Building on the work of the late John Myers, MD, the author has used an intravenous vitamin-and-mineral formula for the treatment of a wide range of clinical conditions. The modified "Myers' cocktail," which consists of magnesium, calcium, B vitamins, and vitamin C, has been found to be effective against acute asthma attacks, migraines, fatigue (including chronic fatigue syndrome), fibromyalgia, acute muscle spasm, upper respiratory tract infections, chronic sinusitis, seasonal allergic rhinitis, cardiovascular disease, and other disorders.
Two very different recent papers come to a similar conclusion: cyclical, physiologic hormone replacement therapy (HRT) may aid memory in postmenopausal women.
One paper found native progesterone, as it is in its natural state cycling the body, helps memory early post-menopause. The other paper found cyclic, physiologic, administered estrogen helps memory after induced menopause.
“Together these results point toward the importance of maintaining hypothalamic-pituitary-gonadal (reproductive system) hormone balance for optimal cognitive performance,” says Wisconsin Alzheimer’s Institute Research Director Craig Atwood, uninvolved in the studies.
Most of us are familiar with the functions of testosterone. Increased libido, mood regulation and feelings of well-being, increased muscle tissue, high bone density, and the prevention of unwanted body fat are just a few of testosterone's responsibilities. Not to mention peak mental acuity and the prevention of heart disease! It all starts deep inside the brain with the anterior pituitary gland, which is the trigger that releases lutenizing hormone (LH) into the blood. LH then stimulates the Leydig cells in the testicles to increase testosterone production.
Last week’s Journal of American Medical Association (JAMA) published a retrospective study that was performed at the Veteran’s Administration (VA) hospital system. While it has long been known that testosterone replacement therapy (TRT) improves sexual function, bone density lean body mass, and improves lipids, this study concluded that testosterone therapy may increase the risk of cardiovascular problems in men with a history of heart disease. It cautioned that men with pre-existing cardiovascular problems and testosterone deficiency should avoid TRT. Several problems with the VA study are obvious after reviewing its data. This press release reviews each of those deficiencies.
Life Extension claims flawed testosterone analysis published in the Journal of the American Medical Association (JAMA) spurs misleading media headlines. FORT LAUDERDALE, Fla., Nov. 12, 2013 /PRNewswire/ -- The recent study, "Association of Testosterone Therapy With Mortality, Myocardial Infarction, and Stroke in Men With Low Testosterone Levels" published Nov. 5 in the Journal of the American Medical Association (JAMA), is flawed and will discourage aging men from properly restoring their testosterone levels, according to a review by Life Extension scientific and medical staff affiliated with the Fort Lauderdale, Fla.-based longevity organization.
Many males over the age of 30 suffer from low testosterone, the primary male sex hormone related to overall male health. When within normal testosterone range, males display an increase in protein synthesis and lean muscle development as well as better overall physical and psychological health. Low testosterone levels have been found to correlate with physiological disorders ranging from Cardio Vascular Disease to Type II Diabetes. Men suffering from low testosterone have even been observed to exhibit psychological symptoms such as anxiety and depression. Males over the age of 30 who suffer from low testosterone are eligible for testosterone replacement therapy, commonly known as TRT. TRT is steadily becoming a standard in treatment for males exhibiting appropriate symptoms. Though much more research is needed, current data supports the use of TRT treatment in symptomatic males over 30 to improve overall male health.
Men with low testosterone levels after age 40 have a higher risk of death over a four-year period than those with normal levels of the hormone, a new study suggests. It's not clear, however, if the two are directly related, and researchers say that it's possible a third unknown factor is responsible for both low testosterone levels and increased mortality. The study, led by Molly Shores of the VA Puget Sound Health Care System and the University of Washington, Seattle, is detailed in the current issue of Archives of Internal Medicine.
Defy Medical restores optimal levels of Human Growth Hormone using a more effective approach. We combine an effective dosage of Sermorelin with bio-identical hormones like testosterone to increase lean muscle tissue, reduce bodyfat, and improve overall health and longevity.
Click here to read more
SAN DIEGO – Testosterone replacement therapy is not associated with an increased risk of cancer or prostate cancer in men, based on results from a large study with a mean follow-up of nearly 9 years.
"We had hoped for these results," Dr. Michael L. Eisenberg said in an interview during a poster session at the annual meeting of the American Urological Association. "Certainly people are worried about testosterone in terms of prostate cancer development."
It is that time of year again where everyone seems to be getting sick. The first thing many people do when they first experience the symptoms of infection is to visit their doctors to seek treatment with antibiotics. Unfortunately, many of the illnesses that spread through communities are actually viral infections which cannot be treated with antibiotics. In addition, antibiotic medications are so prevalently prescribed that the Center for Disease Control (CDC) has issued a warning against their overuse which has resulted in antibiotic resistant “superbugs”. More than 2 million people get antibiotic-resistant infections each year, and at least 23,000 die because current drugs no longer stop their infections.
Excerpt from the book: Testosterone: A Man’s Guide
Most men find that their sexual desire increases after they start testosterone replacement. Sexual dreams and nighttime/morning erections may be more easily achievable, but in some cases testosterone alone does not make erections strong or lasting enough for successful intercourse. So, some men need some extra help to make sure that their improved sex drive matches an improved and hard erection.
These drugs are both available by prescription from compounding pharmacies. These are mixtures of prostaglandins and papaverine that increase blood flow and retention into the penis. Prostaglandins are mediators and have a variety of strong physiological effects, such as regulating the contraction and relaxation of smooth muscle tissue. Prostaglandins are not hormones and they are not produced at one discrete site, but rather in many places throughout the human body.
Men with low testosterone levels after age 40 have a higher risk of death over a four-year period than those with normal levels of the hormone, a new study suggests.
It's not clear, however, if the two are directly related, and researchers say that it's possible a third unknown factor is responsible for both low testosterone levels and increased mortality.
The study, led by Molly Shores of the VA Puget Sound Health Care System and the University of Washington, Seattle, is detailed in the current issue of Archives of Internal Medicine.
The Oregonian (5/16, Muldoon, 237K) reports, "A study published online today in the journal Spine indicates erectile dysfunction may be linked to prescription painkillers known as opioids." After examining data on some 11,327 men undergoing treatment for back pain, researchers found that "long-term opioid use increased by 50 percent the likelihood of also getting an ED prescription."
The Milwaukee Journal Sentinel (5/16, Fauber, 221K) "Pulse" blog reports, "Opioid use is known to lower testosterone levels." Patients "prescribed an opioid daily dose of more than 120 milligrams of morphine equivalent were 58% more likely to be getting an ED or testosterone drug."
COLUMBIA, Mo. – Sporting events can bring a community together, such as when the Louisville Cardinals won the NCAA championship and University of Louisville campus was filled with camaraderie. They also can fuel bitter rivalries, such as the long-standing animosity between the St. Louis Cardinals and the Chicago Cubs. A University of Missouri study has found that testosterone levels during group competition are modulated depending on the relationships among the competitors and may be related to the formation of alliances in warfare.
Now that the warmer weather has come and summer time is right around the corner, the need for sun protection is at its peak. Daily sun exposure can wreak havoc on your skin and have a cumulative effect on its appearance. Whether you get outside once a day to walk your dog or you are a sun goddess bathing in tanning oils for hours on end, the sun is damaging your skin from the moment you step outside. Sun damage is the result of constant UV exposure and limited protection against it. Sun bathing, sunburns, tanning beds, and incorrect use of sunscreen all contribute to the risk of sun damage. Dull uneven tone, freckles, dark marks, age spots and Melasma from pregnancy are all examples of visible sun damage on your skin.
Growth hormone replacement therapy (GHRT) using recombinant human growth hormone (rhGH) has been embraced by many age management practitioners as one of the most effective methods for opposing somatic senescence currently available. However, its routine use has been controversial because few clinical studies have been performed to determine the potential risks of long-term therapy. Also, certain medical and legal issues have not been resolved causing some practitioners to restrict their use of the product.
A daily dose of 1500 mg L-citrulline [structural formula shown here] rids half of the men who have a mild erection problem of this complaint. Urologists at the University of Foggia draw this conclusion from a study in which 24 men with an average age of 56 participated.
High blood pressure, reduced insulin sensitivity and deteriorating cholesterol balance can all in the long term lead to a stiffening of the blood vessels in the male penis. As a result, the penis can lose its ability to have an erection. Doctors usually deal with this problem by prescribing phosphodiesterase type-5 inhibitors, such as sildenafil.
As we reported more than a year ago in our February 2010 LMR review -- Managing Erectile Dysfunction -- When Viagra Doesn’t -- phosphodiasterase-5 (PDE-5) inhibitors, e.g., sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis), are ineffective in 30-40% of men diagnosed with erectile dysfunction (ED). Why? Because the PDE-5 inhibitors help restore erectile function by selectively blocking normal hydrolysis of cGMP, thus promoting cGMP accumulation and partially reversing deficiencies in the NO/cGMP pathway. The key word here is “partially” since insufficient production of NO precludes the formation of sufficient cGMP to enable benefit from a PDE-5 inhibitor.
Coronary heart disease is a leading cause of premature death in men. Epidemiological studies have shown a high prevalence of low serum testosterone levels in men with cardiovascular disease. Furthermore, low testosterone is associated in some but not all observational studies with an increase in cardiovascular events and mortality. Testosterone has beneficial effects on several cardiovascular risk factors which include cholesterol, endothelial dysfunction and inflammation; key mediators of atherosclerosis.
Here are some tips to keep yourself in optimal health as you age.
L-carnitine significantly improves cardiac health in patients after a heart attack, say a multicenter team of investigators in a study published today in Mayo Clinic Proceedings. Their findings, based on analysis of key controlled trials, associate L-carnitine with significant reduction in death from all causes and a highly significant reduction in ventricular arrhythmias and anginal attacks following a heart attack, compared with placebo or control.
Heart disease is the leading cause of death in the United States. Although many of the therapies developed in recent decades have markedly improved life expectancy, adverse cardiovascular events such as ventricular arrhythmias and angina attacks still occur frequently after an acute myocardial infarction (heart attack).
Recent evidence provides the final nail in the coffin for what had been a guiding principle of oncology for >70 yr: the androgen hypothesis of prostate cancer (PCa). It is time to face facts. Prostate cancer risk is unrelated to serum androgen concentrations. High T does not predispose to PCa and low T is not protective. The truth is there was never any credible evidence to support a generalized theory that high T was dangerous and low T protective.
Are you experiencing fatigue and lack of drive? Do you seem to have less mental focus? Do you have less tolerance to stress? Are you feeling depressed? Is your body getting softer while you are gaining fat? Have you been consistently exercising without seeing improvements in your body? You do not have the problems mentioned but you want to understand how to keep your testosterone within healthy ranges? Then testing and knowing the amount of testosterone you have can benefit you. You may be one of the 13 million men in the United States that are suffering from testosterone deficiency needlessly without knowing it. The Defy Medical team will explain in clear and practical language the symptoms and treatments of testosterone deficiency to help determine if you are a good candidate for this therapy.
I have heard of so many mistakes being made by people taking testosterone replacement therapy. Some mistakes seriously impacted their quality of life, or resulted in men stopping testosterone prematurely. Here are a few of the biggest errors I’ve witnessed:
Using “street sources” of testosterone: I have met many men whose doctors do not support their use of testosterone or who have no insurance and access to testosterone replacement therapy, so they buy it on the black market or from dealers at their gyms or social circles. Testosterone is classified as a controlled substance under the Anabolic Steroids Control Act of 1990 and has been assigned to Schedule II or III (depending on the state) by the Drug Enforcement Agency (DEA).
Depression and Type-2 Diabetes are two enemies many men have to fight at some point in their life. Both of these conditions exhibit symptoms which negatively affect a man’s energy level, sexual performance, and overall health& fitness. Evidence supports the benefits Testosterone therapy (TRT) provides men who suffer from either condition. In addition to providing effective treatment for depression and diabetes, TRT can help increase your energy, enhance sexual performance, and lead to improved fitness.